Issue 53, 2022
From the journal:

Chemical Communications

Post-translational site-specific protein azidolation with an azido pyridoxal derivative†

Baochuan Wang,a   Xun Li,a   Yiwan Wang,a   Xianxian Maoab  and  Xiaojian Wang ORCID logo *a  

* Corresponding authors

a Institute of Advanced Synthesis, Institute of Chemical Biology and Functional Molecules, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China
E-mail: ias_xjwang@njtech.edu.cn

b School of Pharmacy, Jiangsu Health Vocational College, Nanjing 211800, China

Abstract

An azido pyridoxal derivative (PLAA) was developed as a protein azidolation reagent, with selectivity towards N-terminal glycine. Successful PLAA modification was achieved with small peptides, natural proteins and lab-expressed proteins under mild conditions, offering a unique method for post-synthesis site-specific azidolation of a peptide or protein.

Graphical abstract: Post-translational site-specific protein azidolation with an azido pyridoxal derivative

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Article information

DOI
https://doi.org/10.1039/D2CC03051A
Article type
Communication
Submitted
30 May 2022
Accepted
05 Jun 2022
First published
06 Jun 2022

Chem. Commun., 2022,58, 7408-7411

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Post-translational site-specific protein azidolation with an azido pyridoxal derivative

B. Wang, X. Li, Y. Wang, X. Mao and X. Wang, Chem. Commun., 2022, 58, 7408 DOI: 10.1039/D2CC03051A

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