Issue 59, 2022
From the journal:

Chemical Communications

Effects of sidechain isomerism on polymer-based non-covalent protein delivery†

Alfonso Barrios,a   Mario Milan,a   Elianny Perozo,a   Md Lokman Hossen, ORCID logo b   Prem Chapagain ORCID logo bc  and  Joong Ho Moon ORCID logo *ac  

* Corresponding authors

a Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th St., Miami, FL, USA
E-mail: jmoon@fiu.edu

b Department of Physics, Florida International University, 11200 SW 8th St., Miami, FL, USA

c Biomolecular Sciences Institute, Florida International University, 11200 SW 8th St., Miami, FL, USA

Abstract

We present the importance of functional group isomerism on intracellular protein delivery using polymers containing different isomeric side chains. While the physical properties of polymer/protein complexes are relatively similar, different planarity of the isomers greatly influences the cellular entry efficiency.

Graphical abstract: Effects of sidechain isomerism on polymer-based non-covalent protein delivery

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Article information

DOI
https://doi.org/10.1039/D2CC02343A
Article type
Communication
Submitted
26 Apr 2022
Accepted
28 Jun 2022
First published
28 Jun 2022

Chem. Commun., 2022,58, 8246-8249

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Effects of sidechain isomerism on polymer-based non-covalent protein delivery

A. Barrios, M. Milan, E. Perozo, M. L. Hossen, P. Chapagain and J. H. Moon, Chem. Commun., 2022, 58, 8246 DOI: 10.1039/D2CC02343A

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