Issue 27, 2022
From the journal:

Chemical Communications

Amphipathic poly-β-peptides for intracellular protein delivery†

Qianyi Ren,‡a   Qi Chen, ORCID logo ‡b   Lanfang Ren,a   Chuntao Cao,b   Runhui Liu ORCID logo *b  and  Yiyun Cheng ORCID logo *a  

* Corresponding authors

a Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, P. R. China
E-mail: yycheng@mail.ustc.edu.cn

b State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, China

Abstract

A series of amphipathic poly-β-peptides are designed for intracellular protein delivery. The poly-β-peptides with higher molecular weight and hydrophobic contents exhibit higher protein loading and superior delivery efficiency. The lead material efficiently delivers proteins into cells with reserved bioactivity.

Graphical abstract: Amphipathic poly-β-peptides for intracellular protein delivery

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Article information

DOI
https://doi.org/10.1039/D2CC00453D
Article type
Communication
Submitted
23 Jan 2022
Accepted
08 Mar 2022
First published
08 Mar 2022

Chem. Commun., 2022,58, 4320-4323

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Amphipathic poly-β-peptides for intracellular protein delivery

Q. Ren, Q. Chen, L. Ren, C. Cao, R. Liu and Y. Cheng, Chem. Commun., 2022, 58, 4320 DOI: 10.1039/D2CC00453D

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