Issue 1, 2021, Issue in Progress
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RSC Advances

Melodinines Y1–Y4, four monoterpene indole alkaloids from Melodinus henryi†

Fa-Lei Zhang,a   Juan He,a   Tao Feng ORCID logo *a  and  Ji-Kai Liu*a  

* Corresponding authors

a School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China
E-mail: tfeng@mail.scuec.edu.cn, jkliu@mail.kib.ac.cn

Abstract

Melodinines Y1–Y4 (1–4), four undescribed alkaloids were isolated from Melodinus henryi. Their structures were elucidated by extensive NMR, mass spectroscopic analyses, theoretical NMR and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 are the first examples of bisindole alkaloids possessing an eburnamine–leuconoxine combination. Compound 3 is a rare 2,3-seco pleiocarpamine type monoterpene indole alkaloid. Compound 1 showed cytotoxic activities against six human cancer cell lines with IC50 values of 0.5–15.2 μM.

Graphical abstract: Melodinines Y1–Y4, four monoterpene indole alkaloids from Melodinus henryi

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Article information

DOI
https://doi.org/10.1039/D0RA09819A
Article type
Paper
Submitted
19 Nov 2020
Accepted
11 Dec 2020
First published
22 Dec 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 23-29

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Melodinines Y1–Y4, four monoterpene indole alkaloids from Melodinus henryi

F. Zhang, J. He, T. Feng and J. Liu, RSC Adv., 2021, 11, 23 DOI: 10.1039/D0RA09819A

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