Nonmetal-catalyzed hydroamination of ynamides with amines

Abstract

The first metal-free catalytic regioselective hydroamination of ynamides with primary and secondary amines has been achieved by using TfOH as the catalyst under mild reaction conditions. This appealing strategy provides the corresponding N-arylimines and ethene-1,1-diamines in good to excellent yields with wide functional group tolerance. Furthermore, their applications in 2-aminoindole syntheses have been presented.