Biocompatible perovskite quantum dots with superior water resistance enable long-term monitoring of the H2S level in vivo

Fang Luo; Shiqing Li; Limei Cui; Yexing Zu; Yiting Chen; Da Huang; Zuquan Weng; Zhenyu Lin

doi:10.1039/D1NR02248B

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Biocompatible perovskite quantum dots with superior water resistance enable long-term monitoring of the H₂S level in vivo†

Fang Luo,^ab Shiqing Li,^ab Limei Cui,^ab Yexing Zu,^ab Yiting Chen,^c Da Huang,

*^a Zuquan Weng^ab and Zhenyu Lin

*^b

Author affiliations

* Corresponding authors

^a College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350108, China
E-mail: huangda@fzu.edu.cn

^b Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China
E-mail: zylin@fzu.edu.cn

^c Fujian Provincial University Engineering Research Centre of Green Materials and Chemical Engineering, Minjiang University, Fuzhou, China

Abstract

The application of perovskite quantum dots (PQDs) in biomedical fields such as bioimaging and biosensing has been limited owing to their instability in the physiological environment. Herein, PQDs are innovatively encapsulated into nano-micelles composed of a polyethylene glycol-polycaprolactone (PEG-PCL) block copolymer, which allows the preparation of biocompatible PQDs (bio-PQDs) with excellent water resistance. Due to the benefits of extraordinary water resistance and biocompatibility, these bio-PQDs are capable of real-time and long-term quantitatively monitoring the H₂S level in living cells as well as in zebrafish.

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Article information

DOI: https://doi.org/10.1039/D1NR02248B
Article type: Communication
Submitted: 11 Apr 2021
Accepted: 26 Jul 2021
First published: 27 Jul 2021

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Nanoscale, 2021,13, 14297-14303

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Biocompatible perovskite quantum dots with superior water resistance enable long-term monitoring of the H₂S level in vivo

F. Luo, S. Li, L. Cui, Y. Zu, Y. Chen, D. Huang, Z. Weng and Z. Lin, Nanoscale, 2021, 13, 14297 DOI: 10.1039/D1NR02248B

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