A microenvironment-mediated Cu2O–MoS2 nanoplatform with enhanced Fenton-like reaction activity for tumor chemodynamic/photothermal therapy

Abstract

Chemodynamic therapy (CDT) with selective therapeutic and minimal side effects has attracted increasing attention in recent years. Nevertheless, the limited H₂O₂ and acid contents in the tumor microenvironment suppress the efficiency of the Fenton reaction. To overcome these issues, photothermal therapy (PTT) is employed to amplify the CDT effect and realize synergistic PTT/CDT. Herein, MoS₂ sheets are functionalized with copper (Cu₂O–MoS₂), which integrates enhanced CDT and PTT to combat tumor cells. The 808 nm light activated Cu₂O–MoS₂ nanoplatform appears to be a potential candidate to improve the synergistic effect on the enhanced Fenton-like reaction and photothermal performance.