Issue 4, 2021

A multifunctional Fenton nanoagent for microenvironment-selective anti-biofilm and anti-inflammatory therapy

Abstract

Bacterial biofilm infections are intractable to traditional antibiotic treatment and usually cause persistent inflammation. Chemodynamic therapy (CDT) based on the Fenton reaction has recently emerged as a promising anti-biofilm strategy. However, the therapeutic efficacy of current Fenton agents often suffers from inefficient Fenton activity and lacks anti-inflammatory capability. Herein, FePS3 nanosheets (NSs) are explored for the first time as novel microenvironment-selective therapeutic nanoagents for bacterial biofilm infections with both self-enhanced Fenton activity for an anti-biofilm effect and reactive oxygen species (ROS) scavenging properties for an anti-inflammatory effect. In biofilms with acidic microenvironments, FePS3 NSs release Fe2+ to generate toxic ROS by Fenton reaction and reductive [P2S6]4− to enhance the Fenton activity by reducing Fe3+ to Fe2+. In the surrounding normal tissues with neutral pH, FePS3 NSs scavenge ROS by reductive [P2S6]4− with an anti-inflammatory effect. This work demonstrates multifunctional Fenton nanoagents with microenvironment-selective ROS generation and elimination properties for effective treatment of bacterial biofilm infections with both anti-biofilm and anti-inflammatory effects.

Graphical abstract: A multifunctional Fenton nanoagent for microenvironment-selective anti-biofilm and anti-inflammatory therapy

Supplementary files

Article information

Article type
Communication
Submitted
01 Dec 2020
Accepted
22 Jan 2021
First published
23 Jan 2021

Mater. Horiz., 2021,8, 1264-1271

A multifunctional Fenton nanoagent for microenvironment-selective anti-biofilm and anti-inflammatory therapy

Y. Li, W. Xiu, K. Yang, Q. Wen, L. Yuwen, Z. Luo, X. Liu, D. Yang, X. Xie and L. Wang, Mater. Horiz., 2021, 8, 1264 DOI: 10.1039/D0MH01921F

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