GSH-resistant and highly cytoselective ruthenium(II)-p-cymene-(imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol complexes as potential anticancer agents

Binoy Kar; Utpal Das; Sourav De; Sudhindra Pete; Ajay Sharma S; Nilmadhab Roy; Ashok Kumar S. K.; Debashis Panda; Priyankar Paira

doi:10.1039/D1DT01604K

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GSH-resistant and highly cytoselective ruthenium(ii)-p-cymene-(imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol complexes as potential anticancer agents†

Binoy Kar,^a Utpal Das,^a Sourav De,

^a Sudhindra Pete,

^a Ajay Sharma S,^a Nilmadhab Roy,^a Ashok Kumar S. K.,^a Debashis Panda

^b and Priyankar Paira

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamilnadu, India
E-mail: priyankar.paira@vit.ac.in
Fax: +91-416-2243092
Tel: +91-416-2243091

^b Department of Basic Sciences and Humanities, Rajiv Gandhi Institute of Petroleum Technology, An Institution of National Importance, Jais, Amethi-229304, Uttar Pradesh, India
E-mail: dpanda@rgipt.ac.in

Abstract

To avoid the side effects of the current popular platinum-based anticancer drugs, researchers have made tireless attempts to design appropriate GSH-resistant Ru(II)-arene complexes. In this regard, luminescent ruthenium(II)-p-cymene-imidazophenanthroline complexes were developed as promising highly cytoselective cancer theraputic agents for HeLa and Caco-2 cells.

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Article information

DOI: https://doi.org/10.1039/D1DT01604K
Article type: Communication
Submitted: 18 May 2021
Accepted: 12 Jul 2021
First published: 12 Jul 2021

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Dalton Trans., 2021,50, 10369-10373

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GSH-resistant and highly cytoselective ruthenium(II)-p-cymene-(imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol complexes as potential anticancer agents

B. Kar, U. Das, S. De, S. Pete, A. Sharma S, N. Roy, A. K. S. K., D. Panda and P. Paira, Dalton Trans., 2021, 50, 10369 DOI: 10.1039/D1DT01604K

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Dalton Transactions

GSH-resistant and highly cytoselective ruthenium(ii)-p-cymene-(imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol complexes as potential anticancer agents†

Abstract

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Article information

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GSH-resistant and highly cytoselective ruthenium(II)-p-cymene-(imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol complexes as potential anticancer agents

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