Issue 99, 2021

Tandem vinyl radical Minisci-type annulation on pyridines: one-pot expeditious access to azaindenones

Abstract

A new regiospecific alkylative/alkenylative cascade annulation of pyridines has been achieved whilst the corresponding classic Minisci alkylative annulation failed. This protocol provides a novel and expeditious access to azaindenones and related compounds via cross-dehydrogenative coupling with the long-standing problem of C2/C4 regioselectivity of pyridines being well addressed.

Graphical abstract: Tandem vinyl radical Minisci-type annulation on pyridines: one-pot expeditious access to azaindenones

Supplementary files

Article information

Article type
Communication
Submitted
03 Nov 2021
Accepted
23 Nov 2021
First published
24 Nov 2021

Chem. Commun., 2021,57, 13570-13573

Tandem vinyl radical Minisci-type annulation on pyridines: one-pot expeditious access to azaindenones

D. Xia and X. Duan, Chem. Commun., 2021, 57, 13570 DOI: 10.1039/D1CC06204B

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