An efficient enantioselective [3+2] cycloaddition of isomünchnones with methyleneindolinones that are generated by an in situ intramolecular addition of the carbonyl group to rhodium carbenes is realized with a chiral N,N′-dioxide/Zn(II) complex as a Lewis acid. A series of chiral oxa-bridged 3-spiropiperidines are obtained in high yields with excellent dr and excellent ee values.
![Graphical abstract: Catalytic asymmetric [3+2] cycloaddition of isomünchnones with methyleneindolinones](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D1CC03685H&imageInfo.ImageIdentifier.Year=2021)
K. Wang, C. Xu, X. Hu, Y. Zhou, L. Lin and X. Feng, Chem. Commun., 2021, 57, 8917 DOI: 10.1039/D1CC03685H
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...
