Issue 92, 2021
From the journal:

Chemical Communications

A functional and self-assembling octyl-phosphonium-tagged esculetin as an effective siRNA delivery agent†

Altab Shaikh, ORCID logo ab   Praveen Kumar Neeli,bc   Gajalakshmi Singuru,bc   Sravya Panangipalli,c   Rajkumar Banerjee, ORCID logo bc   Sridhar Reddy Maddi,bc   Rajamannar Thennati,d   Surendar Reddy Bathulaab  and  Srigiridhar Kotamraju ORCID logo *bc  

* Corresponding authors

a Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad-500007, India

b Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201 002, India

c Department of Applied Biology, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad-500007, India
E-mail: giridhar@iict.res.in

d Sun Pharmaceutical Industries Ltd, Vadodara-390012, India

Abstract

Herein, we document a self-assembling octyl-TPP tagged esculetin (Mito-Esc) as functionally active and as a novel small molecule siRNA delivery vector. While Mito-Esc itself induces selective breast cancer cell death, the amphiphilic nature of Mito-Esc delivers therapeutic siRNAs intracellularly without the need for any excipient to exacerbate the anti-proliferative effects.

Graphical abstract: A functional and self-assembling octyl-phosphonium-tagged esculetin as an effective siRNA delivery agent

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Article information

DOI
https://doi.org/10.1039/D1CC03497A
Article type
Communication
Submitted
06 Jul 2021
Accepted
17 Oct 2021
First published
20 Oct 2021

Chem. Commun., 2021,57, 12329-12332

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A functional and self-assembling octyl-phosphonium-tagged esculetin as an effective siRNA delivery agent

A. Shaikh, P. K. Neeli, G. Singuru, S. Panangipalli, R. Banerjee, S. R. Maddi, R. Thennati, S. R. Bathula and S. Kotamraju, Chem. Commun., 2021, 57, 12329 DOI: 10.1039/D1CC03497A

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