Issue 22, 2021

Multivalent Sgc8c-aptamer decorated polymer scaffolds for leukemia targeting

Abstract

T-cell acute lymphoblastic leukemia causes a disproportional amount of immature white blood cells in the patients’ bone marrow. The significant undesired side effects associated with traditional chemotherapy treatment prompted us to study a more effective treatment strategy. We decorated polyisocyanopeptide scaffolds with the selective leukemia cell binding aptamer sgc8c and found that the polymers inhibit proliferation by G0/G1-phase arrest, serving as an opportunity for future therapeutic strategies.

Graphical abstract: Multivalent Sgc8c-aptamer decorated polymer scaffolds for leukemia targeting

Supplementary files

Article information

Article type
Communication
Submitted
17 Dec 2020
Accepted
04 Feb 2021
First published
04 Feb 2021
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2021,57, 2744-2747

Multivalent Sgc8c-aptamer decorated polymer scaffolds for leukemia targeting

Z. Zhang, C. Tang, R. Hammink, F. H. T. Nelissen, H. A. Heus and P. H. J. Kouwer, Chem. Commun., 2021, 57, 2744 DOI: 10.1039/D0CC08205H

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