Issue 22, 2021

Introducing a squaramide-based self-immolative spacer for controlled drug release

Abstract

Herein we report the design, synthesis and assessment of the first example of a squaramide-based self-immolative system triggered by an enzymatic reduction. We have proved that the release of the alkylating agent N′,N-(bis(2-chloroethyl)benzene)-1,4-diamine (ANM) provokes a dramatic reduction of the survival factor in glioblastoma cells, evidencing the suitability of the squaramide-based spacer for drug delivery applications.

Graphical abstract: Introducing a squaramide-based self-immolative spacer for controlled drug release

Supplementary files

Article information

Article type
Communication
Submitted
23 Nov 2020
Accepted
09 Feb 2021
First published
10 Feb 2021

Chem. Commun., 2021,57, 2736-2739

Introducing a squaramide-based self-immolative spacer for controlled drug release

M. Ximenis, A. Sampedro, L. Martínez-Crespo, G. Ramis, F. Orvay, A. Costa and C. Rotger, Chem. Commun., 2021, 57, 2736 DOI: 10.1039/D0CC07683J

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