Issue 17, 2021

Manganese dioxide nanozyme for reactive oxygen therapy of bacterial infection and wound healing

Abstract

Reactive oxygen species (ROS) are the weapons of neutrophiles against bacterial pathogens, and also the central effectors in reactive oxygen therapy for skin and soft tissue infection. Nanozymes that spontaneously generate ROS under physiological conditions are new antibacterials that hold promise towards multidrug resistant pathogens. The clinical use of the nanozymes is however limited by their low biocompatibility and toxicity in vivo. Here, we develop an oleic acid (OA) nanoemulsion template method for the one-pot synthesis of OA-manganese dioxide (MnO2) nanozyme. The OA-MnO2 nanozyme showed high stability and biocompatibility under physiological conditions with marked oxidase-like activity. The ROS generated by the OA-MnO2 nanozyme effectively kill the Gram-positive Staphylococcus aureus and the Gram-negative Escherichia coli strains. Moreover, the OA-MnO2 nanozyme shows promising abilities to prevent and destruct biofilm formation by Staphylococcus aureus, and result in superior in vivo antibacterial performance as compared to vancomycin. The reactive oxygen therapy based on OA-MnO2 nanozyme cures the infected skin and promotes wound healing in mice, manifesting its potential use in skin and soft tissue infection.

Graphical abstract: Manganese dioxide nanozyme for reactive oxygen therapy of bacterial infection and wound healing

Supplementary files

Article information

Article type
Paper
Submitted
02 May 2021
Accepted
06 Jul 2021
First published
08 Jul 2021

Biomater. Sci., 2021,9, 5965-5976

Manganese dioxide nanozyme for reactive oxygen therapy of bacterial infection and wound healing

L. Liu, C. Wang, Y. Li, L. Qiu, S. Zhou, P. Cui, P. Jiang, X. Ni, R. Liu, X. Du, J. Wang and J. Xia, Biomater. Sci., 2021, 9, 5965 DOI: 10.1039/D1BM00683E

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