Issue 37, 2020

Two-in-one strategy for fluorene-based spirocycles via Pd(0)-catalyzed spiroannulation of o-iodobiaryls with bromonaphthols

Abstract

Rapid assembly of fluorene-based spirocycles represents a highly significant but challenging task in organic synthesis. Reported herein is a novel Pd(0)-catalyzed [4+1] spiroannulation of simple o-iodobiaryls with bromonaphthols for the one-step construction of [4,5]-spirofluorenes in high yields with excellent functional group tolerance. Noteworthily, these valuable fluorene-based coumarin skeletons can enrich the database of C-coumarins and exhibit excellent spectroscopic properties.

Graphical abstract: Two-in-one strategy for fluorene-based spirocycles via Pd(0)-catalyzed spiroannulation of o-iodobiaryls with bromonaphthols

Supplementary files

Article information

Article type
Edge Article
Submitted
10 Aug 2020
Accepted
08 Sep 2020
First published
08 Sep 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2020,11, 10198-10203

Two-in-one strategy for fluorene-based spirocycles via Pd(0)-catalyzed spiroannulation of o-iodobiaryls with bromonaphthols

B. Tan, L. Liu, H. Zheng, T. Cheng, D. Zhu, X. Yang and X. Luan, Chem. Sci., 2020, 11, 10198 DOI: 10.1039/D0SC04386A

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