Issue 63, 2020, Issue in Progress

Diastereoselective synthesis of CF3-dihydrobenzofurans by [4+1] annulation of in situ-generated CF3-o-quinone methides and sulfur ylides

Abstract

An efficient and highly diastereoselective synthesis of CF3-dihydrobenzofurans by the reaction of in situ-generated CF3-oQMs in the presence of a base with sulphur ylides is put forward. The generality of the present developed method was well studied with diverse substrates to access the corresponding products in excellent yields. The highly reactive CF3-oQM has been utilized first time for the annulation reaction.

Graphical abstract: Diastereoselective synthesis of CF3-dihydrobenzofurans by [4+1] annulation of in situ-generated CF3-o-quinone methides and sulfur ylides

Supplementary files

Article information

Article type
Paper
Submitted
26 Aug 2020
Accepted
29 Sep 2020
First published
20 Oct 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 38588-38591

Diastereoselective synthesis of CF3-dihydrobenzofurans by [4+1] annulation of in situ-generated CF3-o-quinone methides and sulfur ylides

B. K. Jha, J. Prudhviraj, P. S. Mainkar, N. Punna and S. Chandrasekhar, RSC Adv., 2020, 10, 38588 DOI: 10.1039/D0RA08289A

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