Issue 41, 2020

Curcumin-loaded PEGylated mesoporous silica nanoparticles for effective photodynamic therapy

Abstract

Curcumin (Cur) can be used as a photosensitizer in the photodynamic therapy (PDT) of cancer, but its low bioavailability limits further clinical application. A mesoporous silica-based drug delivery system (PEGylated mesoporous silica nanoparticles, MSN-PEG@Cur) was designed to solve the problem. The successful preparation of MSN-PEG@Cur was characterized by several physico-chemistry techniques. The endocytosis, ROS generation and in vitro anti-cancer efficacy of MSN-PEG@Cur were evaluated in detail step by step. The results indicated that MSN-PEG@Cur could be effectively endocytosed into cells and release Cur, which can promptly generate ROS upon irradiation, achieving effective PDT in cancer treatment. This MSNs-based drug delivery system provides an alternative strategy for Cur loading and PDT of cancer.

Graphical abstract: Curcumin-loaded PEGylated mesoporous silica nanoparticles for effective photodynamic therapy

Supplementary files

Article information

Article type
Paper
Submitted
30 May 2020
Accepted
23 Jun 2020
First published
29 Jun 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 24624-24630

Curcumin-loaded PEGylated mesoporous silica nanoparticles for effective photodynamic therapy

G. Kuang, Q. Zhang, S. He and Y. Liu, RSC Adv., 2020, 10, 24624 DOI: 10.1039/D0RA04778C

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