Issue 18, 2020

Visible-light-promoted oxidative halogenation of (hetero)arenes

Abstract

Organic halides are critical building blocks that participate in various cross-coupling reactions. Furthermore, they widely exist as natural products and artificial molecules in drugs with important physiological activities. Although halogenation has been well studied, to the best of our knowledge, studies focussing on sensitive systems (e.g. aryl amines) have not been reported. Herein, we describe a compatible oxidative halogenation of (hetero)arenes with air as the oxidant and halide ions as halide sources under ambient conditions (visible light, air, aqueous system, room temperature, and normal pressure). Moreover, this protocol is practically feasible for gram-scale synthesis, showing potential for industrial application.

Graphical abstract: Visible-light-promoted oxidative halogenation of (hetero)arenes

Supplementary files

Article information

Article type
Communication
Submitted
19 Jun 2020
Accepted
03 Aug 2020
First published
10 Aug 2020

Green Chem., 2020,22, 5989-5994

Visible-light-promoted oxidative halogenation of (hetero)arenes

L. Lu, Y. Li and X. Jiang, Green Chem., 2020, 22, 5989 DOI: 10.1039/D0GC02091E

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