In situ detection of hydroxyl radicals in mitochondrial oxidative stress with a nanopipette electrode

Wenting Chen; Shushu Ding; Jiaren Wu; Guoyue Shi; Anwei Zhu

doi:10.1039/D0CC05889K

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In situ detection of hydroxyl radicals in mitochondrial oxidative stress with a nanopipette electrode†

Wenting Chen,^a Shushu Ding,^a Jiaren Wu,^a Guoyue Shi

*^a and Anwei Zhu

*^a

Author affiliations

* Corresponding authors

^a School of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, East China Normal University, 500 Dong Chuan Road, Shanghai 200241, People's Republic of China
E-mail: awzhu@chem.ecnu.edu.cn

Abstract

A novel nanopipette electrode was facilely constructed for the detection of ˙OH based on the inner surface wettability. The nanopipettes with excellent analytical performance were empolyed for in situ detection of ˙OH changes induced by mitochondrial oxidative stress and further utilized to study the association of ˙OH with Alzheimer's disease.

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DOI: https://doi.org/10.1039/D0CC05889K
Article type: Communication
Submitted: 31 Aug 2020
Accepted: 25 Sep 2020
First published: 25 Sep 2020

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Chem. Commun., 2020,56, 13225-13228

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In situ detection of hydroxyl radicals in mitochondrial oxidative stress with a nanopipette electrode

W. Chen, S. Ding, J. Wu, G. Shi and A. Zhu, Chem. Commun., 2020, 56, 13225 DOI: 10.1039/D0CC05889K

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Chemical Communications

In situ detection of hydroxyl radicals in mitochondrial oxidative stress with a nanopipette electrode†

Abstract

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In situ detection of hydroxyl radicals in mitochondrial oxidative stress with a nanopipette electrode

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