Issue 50, 2020

An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds

Abstract

Herein, we describe the development of a simple, high yielding and stereocontrolled strategy for the synthesis of a series of triazolopiperazines and other biologically relevant fused scaffolds from optically active amino acids. This route was applied to the synthesis of 22 scaffolds containing new, previously inaccessible vectors and used to access a novel analogue of ganaplacide.

Graphical abstract: An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds

Supplementary files

Article information

Article type
Communication
Submitted
15 Apr 2020
Accepted
07 May 2020
First published
11 May 2020
This article is Open Access
Creative Commons BY license

Chem. Commun., 2020,56, 6818-6821

An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds

H. L. Stewart, A. R. Hanby, T. A. King, A. D. Bond, T. A. Moss, H. F. Sore and D. R. Spring, Chem. Commun., 2020, 56, 6818 DOI: 10.1039/D0CC02728F

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