Assembly of ruthenium complexes on double stranded DNA using mismatch binding ligands

Abstract

Herein, we show two new DNA binding small molecules, NCD-RO and NCD-RC, and their ability to bind and selectively assemble ruthenium complexes on G–G mismatch DNA. This study used a naphthyridine carbamate dimer (NCD) as an efficient scaffold to assemble metal complexes in a controlled manner on dsDNA.