Issue 37, 2020
From the journal:

Chemical Communications

A multipedal DNA walker for amplified detection of tumor exosomes†

Peng Miao ORCID logo *ab  and  Yuguo Tanga  

* Corresponding authors

a CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, P. R. China
E-mail: miaopeng@sibet.ac.cn, pm3084@nyu.edu

b Department of Chemistry, New York University, New York 10003, USA

Abstract

We have fabricated an ultrasensitive exosome biosensor based on a multipedal DNA walker with a core of target exosomes. Specific recognition is achieved by introducing a CD63 aptamer and facile separation is obtained with magnetic Fe3O4@Au nanoparticles. A limit of detection down to 6/μL is obtained with excellent selectivity.

Graphical abstract: A multipedal DNA walker for amplified detection of tumor exosomes

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Article information

DOI
https://doi.org/10.1039/D0CC01817A
Article type
Communication
Submitted
09 Mar 2020
Accepted
01 Apr 2020
First published
01 Apr 2020

Chem. Commun., 2020,56, 4982-4985

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A multipedal DNA walker for amplified detection of tumor exosomes

P. Miao and Y. Tang, Chem. Commun., 2020, 56, 4982 DOI: 10.1039/D0CC01817A

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