Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi

Mohamed-Elamir F. Hegazy; Tarik A. Mohamed; Abdelsamed I. Elshamy; Ahmed R. Hamed; Mahmoud A. A. Ibrahim; Shinji Ohta; Akemi Umeyama; Paul W. Paré; Thomas Efferth

doi:10.1039/C9RA04158C

Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi†

Mohamed-Elamir F. Hegazy,

^ab Tarik A. Mohamed,^b Abdelsamed I. Elshamy,^cd Ahmed R. Hamed,^b Mahmoud A. A. Ibrahim,

^e Shinji Ohta,^f Akemi Umeyama,^d Paul W. Paré

*^g and Thomas Efferth*^a

Author affiliations

* Corresponding authors

^a Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany

^b Chemistry of Medicinal Plants Department, National Research Centre, El-Tahrir St., Dokki, Giza 12622, Egypt
E-mail: elamir77@live.com, tarik.nrc83@yahoo.com, n1ragab2004@yahoo.com

^c Natural Compound Chemistry Department, National Research Centre, El-Tahrir St., Dokki, Giza 12622, Egypt
E-mail: elshamynrc@yahoo.com

^d Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, Japan
E-mail: umeyama@ph.bunri-u.ac.jp

^e Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt
E-mail: m.ibrahim@compchem.net

^f Graduate School of Biosphere Science, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima 739-8521, Japan
E-mail: ohta@hiroshima-u.ac.jp

^g Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA

Abstract

A solvent extract of the soft coral Sarcophyton ehrenbergi afforded cembrene diterpenoids, sarcoehrenbergilid D–F (1–3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD calculations (TDDFT-ECD). Cytotoxicity activities for 1–3 were evaluated against three human cancer cell lines: lung (A549), colon (Caco-2) and liver (HepG2).

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DOI: https://doi.org/10.1039/C9RA04158C
Article type: Paper
Submitted: 01 Jun 2019
Accepted: 22 Aug 2019
First published: 29 Aug 2019
This article is Open Access

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RSC Adv., 2019,9, 27183-27189

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Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi

M. F. Hegazy, T. A. Mohamed, A. I. Elshamy, A. R. Hamed, M. A. A. Ibrahim, S. Ohta, A. Umeyama, P. W. Paré and T. Efferth, RSC Adv., 2019, 9, 27183 DOI: 10.1039/C9RA04158C

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Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi†

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Sarcoehrenbergilides D–F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi

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