Issue 12, 2019

Sarcoglaucins A-I, new antifouling cembrane-type diterpenes from the South China Sea soft coral Sarcophyton glaucum

Abstract

Nine new cembrane diterpenes, named sarcoglaucins A-I (1–9) along with three known analogues, trochelioid (10), 7α-hydroxy-Δ8(19)-deepoxysarcophine (11), and (−)-sartrochine (12), were isolated from the soft coral Sarcophyton glaucum collected at Xisha Islands in the South China Sea. The structures of all the compounds were established by extensive spectroscopic analysis. The absolute configurations of sarcoglaucins A and B with an unusual [10.3.2.1] cage-type structure were determined using X-ray diffraction and quantum chemical calculation methods. Sarcoglaucin B (2), sarcoglaucin E (5) and compounds 10–12 showed strong antifouling activity against the barnacle Balanus amphitrite.

Graphical abstract: Sarcoglaucins A-I, new antifouling cembrane-type diterpenes from the South China Sea soft coral Sarcophyton glaucum

Supplementary files

Article information

Article type
Research Article
Submitted
17 Mar 2019
Accepted
19 Apr 2019
First published
22 Apr 2019

Org. Chem. Front., 2019,6, 2004-2013

Sarcoglaucins A-I, new antifouling cembrane-type diterpenes from the South China Sea soft coral Sarcophyton glaucum

J. Zhang, X. Tang, X. Han, D. Feng, X. Luo, L. V. Ofwegen, P. Li and G. Li, Org. Chem. Front., 2019, 6, 2004 DOI: 10.1039/C9QO00386J

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