Issue 13, 2019

Efficient and practical synthesis of unsymmetrical disulfides via base-catalyzed aerobic oxidative dehydrogenative coupling of thiols

Abstract

An efficient M2CO3-catalyzed (M = K or Cs) aerobic cross dehydrogenative coupling reaction of thiols was described. This reaction provided an efficient approach to unsymmetrical disulfides which are ubiquitous structures of pharmaceuticals and pesticides. This is the first aerobic oxidative CDC of thiols to unsymmetrical disulfides. The high atom-economy, easy accessibility of catalyst, O2 as the ideal green oxidant, mild reaction conditions, and broad substrate scope demonstrate that the present methodology provides a green, attractive, and practical approach to disulfides.

Graphical abstract: Efficient and practical synthesis of unsymmetrical disulfides via base-catalyzed aerobic oxidative dehydrogenative coupling of thiols

Supplementary files

Article information

Article type
Research Article
Submitted
13 Feb 2019
Accepted
19 Apr 2019
First published
22 Apr 2019

Org. Chem. Front., 2019,6, 2220-2225

Efficient and practical synthesis of unsymmetrical disulfides via base-catalyzed aerobic oxidative dehydrogenative coupling of thiols

X. Qiu, X. Yang, Y. Zhang, S. Song and N. Jiao, Org. Chem. Front., 2019, 6, 2220 DOI: 10.1039/C9QO00239A

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