Issue 8, 2019

Transition-metal-free decarboxylative C3-difluoroarylmethylation of quinoxalin-2(1H)-ones with α,α-difluoroarylacetic acids

Abstract

A facile transition-metal-free decarboxylative radical coupling reaction of α,α-difluoroarylacetic acids with quinoxalin-2(1H)-ones has been developed. This methodology provided a highly attractive approach to synthesize a series of difluoroarylmethylated quinoxalin-2(1H)-ones that contain various functional groups in moderate to good yields under mild conditions. Moreover, experimental studies reveal that the CF2 group of α,α-difluoroarylacetic acids plays a vital role in this transformation.

Graphical abstract: Transition-metal-free decarboxylative C3-difluoroarylmethylation of quinoxalin-2(1H)-ones with α,α-difluoroarylacetic acids

Supplementary files

Article information

Article type
Research Article
Submitted
23 Jan 2019
Accepted
26 Feb 2019
First published
27 Feb 2019

Org. Chem. Front., 2019,6, 1173-1182

Transition-metal-free decarboxylative C3-difluoroarylmethylation of quinoxalin-2(1H)-ones with α,α-difluoroarylacetic acids

G. Hong, J. Yuan, J. Fu, G. Pan, Z. Wang, L. Yang, Y. Xiao, P. Mao and X. Zhang, Org. Chem. Front., 2019, 6, 1173 DOI: 10.1039/C9QO00105K

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