Direct Csp3–H methylenation of 2-arylacetamides using DMF/Me2NH-BH3 as the methylene source†
Abstract
A direct Csp3–H methylenation of 2-arylacetamides using DMF/Me2NH-BH3 as the methylene source was developed. The formyl group of DMF delivered the carbon and one hydrogen atoms, and the Me2NH-BH3 donated the remaining one hydrogen atom. This protocol offers a new alternative to make useful 2-arylacrylamides from simple starting materials.
- This article is part of the themed collection: Synthetic methodology in OBC