Issue 25, 2019

Direct Csp3–H methylenation of 2-arylacetamides using DMF/Me2NH-BH3 as the methylene source

Abstract

A direct Csp3–H methylenation of 2-arylacetamides using DMF/Me2NH-BH3 as the methylene source was developed. The formyl group of DMF delivered the carbon and one hydrogen atoms, and the Me2NH-BH3 donated the remaining one hydrogen atom. This protocol offers a new alternative to make useful 2-arylacrylamides from simple starting materials.

Graphical abstract: Direct Csp3–H methylenation of 2-arylacetamides using DMF/Me2NH-BH3 as the methylene source

Supplementary files

Article information

Article type
Paper
Submitted
18 Apr 2019
Accepted
31 May 2019
First published
31 May 2019

Org. Biomol. Chem., 2019,17, 6153-6157

Direct Csp3–H methylenation of 2-arylacetamides using DMF/Me2NH-BH3 as the methylene source

Y. Liu, C. Wang, H. Xia, Z. Wang and Y. Wang, Org. Biomol. Chem., 2019, 17, 6153 DOI: 10.1039/C9OB00875F

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