Issue 25, 2019

Synthesis of β-sulfinyl cyclobutane carboxylic amides via a formal α to β sulphoxide migration process

Abstract

An original tandem reaction consisting of a thermal elimination–addition process was developed. Highly substituted β-sulfinyl cyclobutane carboxylic acid derivatives were obtained from isomeric α-sulfinyl derivatives in a single operation in good to high yields and with high trans diastereoselectivity.

Graphical abstract: Synthesis of β-sulfinyl cyclobutane carboxylic amides via a formal α to β sulphoxide migration process

Supplementary files

Article information

Article type
Communication
Submitted
02 Apr 2019
Accepted
03 Jun 2019
First published
03 Jun 2019

Org. Biomol. Chem., 2019,17, 6143-6147

Synthesis of β-sulfinyl cyclobutane carboxylic amides via a formal α to β sulphoxide migration process

L. Ghisu, N. Melis, L. Serusi, A. Luridiana, F. Soddu, F. Secci, P. Caboni, R. Guillot, D. J. Aitken and A. Frongia, Org. Biomol. Chem., 2019, 17, 6143 DOI: 10.1039/C9OB00758J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements