Issue 20, 2019

Non-directed copper-catalyzed regioselective C–H sulfonylation of phenothiazines

Abstract

We develop a simple and general method for sulfonylation of phenothiazines under Cu(I) catalysis. The broad scope of aryl/alkyl sulfonyl chlorides was applicable to produce C3 sulfonylation products of phenothiazines in moderate to good yields. The further transformation of the sulfonylation products was successful, which afforded valuable polyheterocycles.

Graphical abstract: Non-directed copper-catalyzed regioselective C–H sulfonylation of phenothiazines

Supplementary files

Article information

Article type
Paper
Submitted
27 Mar 2019
Accepted
23 Apr 2019
First published
23 Apr 2019

Org. Biomol. Chem., 2019,17, 5009-5013

Non-directed copper-catalyzed regioselective C–H sulfonylation of phenothiazines

C. Liu, Y. Shen and K. Yuan, Org. Biomol. Chem., 2019, 17, 5009 DOI: 10.1039/C9OB00705A

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