Issue 18, 2019
From the journal:

New Journal of Chemistry

Nanoreactors for the multi-functionalization of poly-histidine fragments†

Marco Paolino, ORCID logo a   Annalisa Reale,a   Vincenzo Razzano,a   Germano Giuliani,a   Alessandro Donati,a   Claudia Bonechi,a   Gianfranco Caselli,b   Michela Visintin,b   Francesco Makovec,b   Cinzia Scialabba,c   Mariano Licciardi, ORCID logo c   Eugenio Paccagnini,d   Mariangela Gentile,d   Laura Salvini,e   Francesco Tavanti, ORCID logo f   Maria Cristina Menzianif  and  Andrea Cappelli ORCID logo *a  

* Corresponding authors

a Dipartimento di Biotecnologie, Chimica e Farmacia (Dipartimento di Eccellenza 2018-2022), Università di Siena, Via A. Moro 2, 53100 Siena, Italy
E-mail: Andrea.cappelli@unisi.it

b Rottapharm Biotech S.p.A., Via Valosa di Sopra 9, 20900 Monza, Italy

c Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), Università di Palermo, Via Archirafi 32, 90123 Palermo, Italy

d Dipartimento di Scienze della Vita, Università di Siena, Via A. Moro 2, Siena, Italy

e Toscana Life Sciences Foundation, Via Fiorentina 1, 53100 Siena, Italy

f Dipartimento di Scienze Chimiche e Geologiche, Università di Modena e Reggio Emilia, Via Campi 103, 41121 Modena, Italy

Abstract

Water-soluble MBHA derivatives were found to self-assemble in a water environment to generate aggregates showing core–shell architectures. The aggregates appeared to be capable of working as nanoreactors performing a multi-functionalization of poly-histidine fragments, which after an initial interaction with the solvated oligo(ethylene glycol) shell reach the reactive core.

Graphical abstract: Nanoreactors for the multi-functionalization of poly-histidine fragments

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Article information

DOI
https://doi.org/10.1039/C9NJ00279K
Article type
Letter
Submitted
17 Jan 2019
Accepted
05 Apr 2019
First published
05 Apr 2019

New J. Chem., 2019,43, 6834-6837

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Nanoreactors for the multi-functionalization of poly-histidine fragments

M. Paolino, A. Reale, V. Razzano, G. Giuliani, A. Donati, C. Bonechi, G. Caselli, M. Visintin, F. Makovec, C. Scialabba, M. Licciardi, E. Paccagnini, M. Gentile, L. Salvini, F. Tavanti, M. C. Menziani and A. Cappelli, New J. Chem., 2019, 43, 6834 DOI: 10.1039/C9NJ00279K

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