Issue 99, 2019
From the journal:

Chemical Communications

A nanoscale metal–organic framework for combined photodynamic and starvation therapy in treating breast tumors†

Qun Guan, ORCID logo a   Le-Le Zhou,ab   Yan-An Li ORCID logo *a  and  Yu-Bin Dong ORCID logo *a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China
E-mail: yananli@sdnu.edu.cn, yubindong@sdnu.edu.cn

b School of Chemical and Biological Engineering, Qilu Institute of Technology, Jinan 250200, P. R. China

Abstract

We demonstrate herein an effective cascade reaction for combined photodynamic and starvation therapy in treating breast tumors based on a photosensitizer and CO prodrug decorated NMOF. The PDT-induced ROS can further trigger CO release, and the high antitumor efficiency derived from both 1O2 and CO is well confirmed by in vitro assays and in vivo trials.

Graphical abstract: A nanoscale metal–organic framework for combined photodynamic and starvation therapy in treating breast tumors

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Article information

DOI
https://doi.org/10.1039/C9CC07510K
Article type
Communication
Submitted
24 Sep 2019
Accepted
29 Oct 2019
First published
29 Oct 2019

Chem. Commun., 2019,55, 14898-14901

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A nanoscale metal–organic framework for combined photodynamic and starvation therapy in treating breast tumors

Q. Guan, L. Zhou, Y. Li and Y. Dong, Chem. Commun., 2019, 55, 14898 DOI: 10.1039/C9CC07510K

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