Issue 97, 2019

Facile synthesis of 9H-pyrrolo[1,2-a]indoles via Brønsted acid catalyzed cascade reactions

Abstract

An efficient Brønsted acid catalyzed Friedel–Crafts alkenylation/1,6-addition/condensation cascade reaction has been developed. This protocol enables effective access to various highly functionalized 9H-pyrrolo[1,2-a]indoles in moderate to high yields. Mechanistic studies indicate that the in situ vinylogous reactivity intermediate might be formed in the catalytic system.

Graphical abstract: Facile synthesis of 9H-pyrrolo[1,2-a]indoles via Brønsted acid catalyzed cascade reactions

Supplementary files

Article information

Article type
Communication
Submitted
15 Sep 2019
Accepted
11 Nov 2019
First published
11 Nov 2019

Chem. Commun., 2019,55, 14613-14616

Facile synthesis of 9H-pyrrolo[1,2-a]indoles via Brønsted acid catalyzed cascade reactions

K. Xu, W. Chen, J. Lin, G. Chen, B. Wang and X. Tian, Chem. Commun., 2019, 55, 14613 DOI: 10.1039/C9CC07228D

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