Issue 4, 2019
From the journal:

Biomaterials Science

Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands†

R. Fraioli,ab   S. Neubauer,c   F. Rechenmacher,c   B. M. Bosch,d   K. Dashnyam,e   J.-H. Kim,e   R. A. Perez,de   H.-W. Kim, ORCID logo e   F. J. Gil, ORCID logo ad   M. P. Ginebra, ORCID logo abf   J. M. Manero, ORCID logo *ab   H. Kessler ORCID logo c  and  C. Mas-Moruno ORCID logo *ab  

* Corresponding authors

a Biomaterials, Biomechanics and Tissue Engineering Group, Dept. of Materials Science and Metallurgy, Universitat Politècnica de Catalunya, Barcelona, Spain
E-mail: jose.maria.manero@upc.edu, carles.mas.moruno@upc.edu

b Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya, Barcelona, Spain

c Institute for Advanced Study - Center for Integrated Protein Science, Department Chemie, Technische Universität München, Garching, Germany

d Bioengineering Institute of Technology, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain

e Institute of Tissue Regeneration Engineering; Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine; UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan, Republic of Korea

f Institute for Bioengineering of Catalonia, Barcelona, Spain

Abstract

In this communication we report that anchoring αvβ3 or α5β1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.

Graphical abstract: Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands

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Article information

DOI
https://doi.org/10.1039/C8BM01466C
Article type
Communication
Submitted
13 Nov 2018
Accepted
25 Jan 2019
First published
05 Feb 2019

Biomater. Sci., 2019,7, 1281-1285

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Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands

R. Fraioli, S. Neubauer, F. Rechenmacher, B. M. Bosch, K. Dashnyam, J.-H. Kim, R. A. Perez, H.-W. Kim, F. J. Gil, M. P. Ginebra, J. M. Manero, H. Kessler and C. Mas-Moruno, Biomater. Sci., 2019, 7, 1281 DOI: 10.1039/C8BM01466C

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