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Haemolytic and Cellular Toxicology of Sulfanilamide-Based Nonionic Surfactant: A Niosomal Carrier for Hydrophobic Drugs

Abstract

Biocompatible surfactants are of diverse pharmaceutical interest due to their ability to self-assemble into nano-particulate systems and single-step drug loading, based upon hydrophobic-hydrophobic interaction between hydrophobic drug and lipophilic part of surfactant molecule. However, surfactants are associated with cytotoxicity and hemolysis due to their amphiphilic interaction with cellular membrane. This study reports on novel membrane-compatible surfactant, synthesized from sulfanilamide and its self-micellization into niosomes. The surfactant was synthesized in single step reaction via introducing alkyl chain in sulfanilamide moiety by conjugation with deconyl chloride. The synthesized surfactant (S-SDC) was characterized by 1H and 13C NMR, mass spectrometry and single crystal XRD. The S-SDC niosomes were explored for drug delivery with Clarithromycin as a model drug. The biocompatibility of the surfactant was investigated through hemolysis and cytotoxicity. Surfactant presented a very low critical micellar concentration (CMC) of 0.04 mM and entraped 65% of drug which was released in sustained manner, over 12 h, in acidic and physiological pH. The vesicles were spherical in shape with 234 ±3.61 nm mean diameter and narrow size distribution. Niosomes were hemocompatible and nontoxic to cellular membrane. The results suggested sulfanilamide based surfactant as novel and cell membrane compatible niosomal drug delivery vehicle.

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Publication details

The article was received on 12 Apr 2018, accepted on 12 Jun 2018 and first published on 13 Jun 2018


Article type: Paper
DOI: 10.1039/C8TX00108A
Citation: Toxicol. Res., 2018, Accepted Manuscript
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    Haemolytic and Cellular Toxicology of Sulfanilamide-Based Nonionic Surfactant: A Niosomal Carrier for Hydrophobic Drugs

    I. Ali, M. R. Shah, S. Yousaf, S. Ahmed, K. Shah and I. Javed, Toxicol. Res., 2018, Accepted Manuscript , DOI: 10.1039/C8TX00108A

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