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The hypothalamic–pituitary–testicular axis and the testicular function are modulated after silver nanoparticle exposure

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Abstract

Silver nanoparticles (AgNPs) are widely used in industrial and medical applications and humans may be exposed through different routes, increasing the risk of toxicity. We investigated the transcript expression of genes involved in the regulation of the hypothalamic–pituitary–testicular (HPT) axis and the parameters associated with sperm functionality after prepubertal exposure. AgNPs modulated the transcript expression of genes involved in the control of the HPT axis and spermatogenesis in the groups treated with lower doses, while the functional parameters related to sperm and puberty were affected in the groups administered higher doses. These results suggest that the HPT axis is disrupted by AgNPs during the prepubertal and pubertal periods, which are highly susceptible windows for the endocrine-disrupting chemical activity.

Graphical abstract: The hypothalamic–pituitary–testicular axis and the testicular function are modulated after silver nanoparticle exposure

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Publication details

The article was received on 31 Aug 2017, accepted on 22 Nov 2017 and first published on 23 Nov 2017


Article type: Paper
DOI: 10.1039/C7TX00236J
Citation: Toxicol. Res., 2018, Advance Article
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    The hypothalamic–pituitary–testicular axis and the testicular function are modulated after silver nanoparticle exposure

    M. D. Cavallin, R. Wilk, I. M. Oliveira, N. C. S. Cardoso, N. M. Khalil, C. A. Oliveira, M. A. Romano and R. M. Romano, Toxicol. Res., 2018, Advance Article , DOI: 10.1039/C7TX00236J

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