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Kinetic evolution of DOPC lipid bilayers exposed to α-cyclodextrins

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Abstract

Cyclodextrins are cyclic oligosaccharides capable of forming inclusion complexes with a variety of molecules, and as such have been recognized as a pharmaceutical and biotechnological asset. Cyclodextrins are known to interact with the components of cell membranes, and this correlates with a significant degree of cytotoxicity. In this work, we report on the mechanism of degradation of a model dioleoyl-phosphatidylcholine (DOPC) bilayer exposed to a solution with increasing concentrations of α-cyclodextrins. By combining optical fluorescence microscopy and quartz-crystal microbalance experiments, we study the evolution of supported lipid bilayers (SLBs) and giant unilamellar vesicles (GUVs). The rate of lipid removal is found to display a strong nonlinear dependence on the cyclodextrin concentration. A mechanism involving lipid aggregates is proposed.

Graphical abstract: Kinetic evolution of DOPC lipid bilayers exposed to α-cyclodextrins

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Publication details

The article was received on 17 May 2018, accepted on 15 Jun 2018 and first published on 19 Jun 2018


Article type: Paper
DOI: 10.1039/C8SM01013G
Citation: Soft Matter, 2018, Advance Article
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    Kinetic evolution of DOPC lipid bilayers exposed to α-cyclodextrins

    M. Kluzek, M. Schmutz, C. M. Marques and F. Thalmann, Soft Matter, 2018, Advance Article , DOI: 10.1039/C8SM01013G

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