Jump to main content
Jump to site search

Issue 23, 2018
Previous Article Next Article

Probing the self-assembly dynamics and internal structure of amphiphilic hyaluronic acid conjugates by fluorescence spectroscopy and molecular dynamics simulations

Author affiliations

Abstract

Polymeric nanoparticles are increasingly used as biocompatible carriers for drugs and imaging agents. Understanding their self-assembly dynamics and morphology is of ultimate importance to develop nanoformulations with optimal characteristics. To achieve better performance, it is vital to account for cargo–carrier interactions at the molecular level. The self-assembly dynamics were studied and the internal structure of nanoparticles derived from a series of hydrophobically modified hyaluronic acid was revealed. Environment-sensitive ratiometric fluorescent probes provide valuable information about the nanoparticle's interior morphology, and molecular dynamics simulations complement the overall picture with insights into intramolecular and intermolecular interactions of the polymer, as well as its interactions with the small-molecule load. van der Waals and π–π interactions of the hydrophobic side fragments play a leading role in self-assembly and loading of hydrophobic small molecules. Aliphatic substituents form more extensive hydrophobic domains, while aromatic moieties allow more interaction of the loaded small molecules with the surrounding solvent.

Graphical abstract: Probing the self-assembly dynamics and internal structure of amphiphilic hyaluronic acid conjugates by fluorescence spectroscopy and molecular dynamics simulations

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 May 2018, accepted on 05 May 2018 and first published on 08 May 2018


Article type: Paper
DOI: 10.1039/C8SM00908B
Citation: Soft Matter, 2018,14, 4762-4771
  •   Request permissions

    Probing the self-assembly dynamics and internal structure of amphiphilic hyaluronic acid conjugates by fluorescence spectroscopy and molecular dynamics simulations

    D. Svechkarev, A. Kyrychenko, W. M. Payne and A. M. Mohs, Soft Matter, 2018, 14, 4762
    DOI: 10.1039/C8SM00908B

Search articles by author

Spotlight

Advertisements