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Nonequilibrium phase diagrams for actomyosin networks

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Abstract

Living cells dynamically modulate the local morphologies of their actin networks to perform biological functions, including force transduction, intracellular transport, and cell division. A major challenge is to understand how diverse structures of the actin cytoskeleton are assembled from a limited set of molecular building blocks. Here we study the spontaneous self-assembly of a minimal model of cytoskeletal materials, consisting of semiflexible actin filaments, crosslinkers, and molecular motors. Using coarse-grained simulations, we demonstrate that by changing concentrations and kinetics of crosslinkers and motors, as well as filament lengths, we can generate three distinct structural phases of actomyosin assemblies: bundled, polarity-sorted, and contracted. We introduce new metrics to distinguish these structural phases and demonstrate their functional roles. We find that the binding kinetics of motors and crosslinkers can be tuned to optimize contractile force generation, motor transport, and mechanical response. By quantitatively characterizing the relationships between the modes of cytoskeletal self-assembly, the resulting structures, and their functional consequences, our work suggests new principles for the design of active materials.

Graphical abstract: Nonequilibrium phase diagrams for actomyosin networks

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Publication details

The article was received on 10 Apr 2018, accepted on 24 Aug 2018 and first published on 30 Aug 2018


Article type: Paper
DOI: 10.1039/C8SM00741A
Citation: Soft Matter, 2018, Advance Article
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    Nonequilibrium phase diagrams for actomyosin networks

    S. L. Freedman, G. M. Hocky, S. Banerjee and A. R. Dinner, Soft Matter, 2018, Advance Article , DOI: 10.1039/C8SM00741A

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