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Mesoporous magnetic silica particles modified with stimuli-responsive P(NIPAM-DMA) valve for controlled loading and release of biologically active molecules

Abstract

Mesoporous magnetic silica particles bearing stimuli-responsive polymer valve have been prepared and evaluated the performance as a microcapsule. In this study, first, mesoporous magnetic iron oxide (Fe3O4) particles are prepared by solvothermal method. Then magnetic particles are coated with silica and functionalized with vinyl groups using 3-(trimethoxysilyl)-propyl methacrylate (MPS). Subsequently, Fe3O4/SiO2 composite particles grafted with MPS are used to carry out seeded precipitation copolymerization of N-isopropylacrylamide (NIPAM) and 2,2-dimethylaminoethyl methacrylate (DMA). Here N,N'-methylenebisacrylamide (MBA) has been used as cross-linker. Brunauer–Emmett–Teller (BET) surface analysis suggested that mesoporous structure is retained in the final Fe3O4/SiO2/P(NIPAM-DMA-MBA) composite hydrogel particles. The prepared Fe3O4/SiO2/P(NIPAM-DMA-MBA) composite hydrogel microspheres exhibited pH dependent volume phase transition. At lower pH value (< 7) inclusion of DMA shifted the volume phase transition to higher temperature because of the protonation of tertiary amine groups. The composite hydrogel particles possessed high saturation magnetization (51 emu/g) and moved under the influence of external magnetic field. The loading-release behaviour of biologically active molecules suggested that a portion of encapsulated guest molecules is released at temperature below the lower critical solution temperature, LCST (<35 °C).

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Publication details

The article was received on 18 Mar 2018, accepted on 06 Jun 2018 and first published on 08 Jun 2018


Article type: Paper
DOI: 10.1039/C8SM00560E
Citation: Soft Matter, 2018, Accepted Manuscript
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    Mesoporous magnetic silica particles modified with stimuli-responsive P(NIPAM-DMA) valve for controlled loading and release of biologically active molecules

    M. Tanjim, M. A. Rahman, M. M. Rahman, H. Minami, S. M. Hoque, M. K. Sharafat, M. A. Gafur and H. Ahmad, Soft Matter, 2018, Accepted Manuscript , DOI: 10.1039/C8SM00560E

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