Jump to main content
Jump to site search


Spontaneous domain formation in disordered copolymers as a mechanism for chromosome structuring

Author affiliations

Abstract

Motivated by the problem of domain formation in chromosomes, we studied a co-polymer model where only a subset of the monomers feel attractive interactions. These monomers are displaced randomly from a regularly-spaced pattern, thus introducing some quenched disorder in the system. Previous work has shown that in the case of regularly-spaced interacting monomers this chain can fold into structures characterized by multiple distinct domains of consecutive segments. In each domain, attractive interactions are balanced by the entropy cost of forming loops. We show by advanced replica-exchange simulations that adding disorder in the position of the interacting monomers further stabilizes these domains. The model suggests that the partitioning of the chain into well-defined domains of consecutive monomers is a spontaneous property of heteropolymers. In the case of chromosomes, evolution could have acted on the spacing of interacting monomers to modulate in a simple way the underlying domains for functional reasons.

Graphical abstract: Spontaneous domain formation in disordered copolymers as a mechanism for chromosome structuring

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Mar 2018, accepted on 21 Jun 2018 and first published on 28 Jun 2018


Article type: Paper
DOI: 10.1039/C8SM00468D
Citation: Soft Matter, 2018, Advance Article
  •   Request permissions

    Spontaneous domain formation in disordered copolymers as a mechanism for chromosome structuring

    M. Negri, M. Gherardi, G. Tiana and M. Cosentino Lagomarsino, Soft Matter, 2018, Advance Article , DOI: 10.1039/C8SM00468D

Search articles by author

Spotlight

Advertisements