Jump to main content
Jump to site search

Issue 19, 2018
Previous Article Next Article

From jamming to collective cell migration through a boundary induced transition

Author affiliations

Abstract

Cell monolayers provide an interesting example of active matter, exhibiting a phase transition from flowing to jammed states as they age. Here we report experiments and numerical simulations illustrating how a jammed cellular layer rapidly reverts to a flowing state after a wound. Quantitative comparison between experiments and simulations shows that cells change their self-propulsion and alignment strength so that the system crosses a phase transition line, which we characterize by finite-size scaling in an active particle model. This wound-induced unjamming transition is found to occur generically in epithelial, endothelial and cancer cells.

Graphical abstract: From jamming to collective cell migration through a boundary induced transition

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Jan 2018, accepted on 20 Apr 2018 and first published on 01 May 2018


Article type: Paper
DOI: 10.1039/C8SM00128F
Citation: Soft Matter, 2018,14, 3774-3782
  •   Request permissions

    From jamming to collective cell migration through a boundary induced transition

    O. Chepizhko, M. C. Lionetti, C. Malinverno, C. Giampietro, G. Scita, S. Zapperi and C. A. M. La Porta, Soft Matter, 2018, 14, 3774
    DOI: 10.1039/C8SM00128F

Search articles by author

Spotlight

Advertisements