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Issue 19, 2018
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Adsorption of phospholipids at oil/water interfaces during emulsification is controlled by stress relaxation and diffusion

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Abstract

Adsorption of phosphatidylcholines at oil/water interfaces strongly deviates from spread monolayers at air/water surfaces. Understanding its nature and consequences could vastly improve applications in medical nanoemulsions and biotechnologies. Adsorption kinetics at interfaces of water with different oil phases were measured by profile analysis tensiometry. Adsorption kinetics for 2 different phospholipids, DPPC and POPC, as well as 2 organic phases, squalene and squalane, show that formation of interfacial monolayers is initially dominated by stress-relaxation in the first minutes. Diffusion only gradually contributes to a decrease in interfacial tension at later stages of time and higher film pressures. The results can be applied for the optimization of emulsification protocols using mechanical treatments. Emulsions using phospholipids with unsaturated fatty acids are dominated much more strongly by stress-relaxation and cover interfaces very fast compared to those with saturated fatty acids. In contrast, phospholipid layers consisting of saturated fatty acids converge faster towards the equilibrium than those with unsaturated fatty acids.

Graphical abstract: Adsorption of phospholipids at oil/water interfaces during emulsification is controlled by stress relaxation and diffusion

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Publication details

The article was received on 01 Jan 2018, accepted on 08 Apr 2018 and first published on 10 Apr 2018


Article type: Paper
DOI: 10.1039/C8SM00005K
Citation: Soft Matter, 2018,14, 3730-3737
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    Adsorption of phospholipids at oil/water interfaces during emulsification is controlled by stress relaxation and diffusion

    E. Hildebrandt, H. Nirschl, R. J. Kok and G. Leneweit, Soft Matter, 2018, 14, 3730
    DOI: 10.1039/C8SM00005K

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