Graftable SCoMPIs enable the labeling and X-Ray fluorescence imaging of proteins $(document).ready(function() { if (!$("html").hasClass("ie8")) { $.ajax({ url: "https://crossmark-cdn.crossref.org/widget/v2.0/widget.js", dataType: "script", cache: true }).done(function() { $(".crossmark-button").addClass("visible"); }); } });

Abstract

Bio-imaging techniques alternative to fluorescence microscopy are gaining increasing interest as com-plementary tools to visualize and interrogate biolog-ical systems. Among them, X-ray fluorescence mi-crospectroscopy provides information on the local content and distribution of heavy elements (Z≥14) in cells or biological samples. In this context, simi-lar tools to those developed for fluorescence mi-croscopy are desired, including chemical probes or tags. In this work, we study rhenium complexes as a convenient and sensitive probe for X-Ray Fluores-cence microspectroscopy. We demonstrate their ability to label and sense exogenously incubated or endogenous proteins inside cells.