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Issue 38, 2018
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A practically simple, catalyst free and scalable synthesis of N-substituted ureas in water

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Abstract

A practically simple, mild and efficient method is developed for the synthesis of N-substituted ureas by nucleophilic addition of amines to potassium isocyanate in water without organic co-solvent. Using this methodology, a variety of N-substituted ureas (mono-, di- and cyclic-) were synthesized in good to excellent yields with high chemical purity by applying simple filtration or routine extraction procedures avoiding silica gel purification. The developed methodology was also found to be suitable for gram scale synthesis of molecules having commercial application in large volumes. The identified reaction conditions were found to promote a unique substrate selectivity from a mixture of two amines.

Graphical abstract: A practically simple, catalyst free and scalable synthesis of N-substituted ureas in water

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Publication details

The article was received on 02 May 2018, accepted on 03 Jun 2018 and first published on 13 Jun 2018


Article type: Paper
DOI: 10.1039/C8RA03761B
Citation: RSC Adv., 2018,8, 21585-21595
  • Open access: Creative Commons BY-NC license
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    A practically simple, catalyst free and scalable synthesis of N-substituted ureas in water

    L. Tiwari, V. Kumar, B. Kumar and D. Mahajan, RSC Adv., 2018, 8, 21585
    DOI: 10.1039/C8RA03761B

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