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Issue 9, 2018, Issue in Progress
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Systematic investigation of functional ligands for colloidal stable upconversion nanoparticles

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Abstract

Despite intense efforts on surface functionalization to generate hydrophilic upconversion nanoparticles (UCNPs), long-term colloidal stability in physiological buffers remains a major concern. Here we quantitatively investigate the competitive adsorption of phosphate, carboxylic acid and sulphonic acid onto the surface of UCNPs and study their binding strength to identify the best conjugation strategy. To achieve this, we designed and synthesized three di-block copolymers composed of poly(ethylene glycol) methyl ether acrylate and a polymer block bearing phosphate, carboxylic or sulphonic acid anchoring groups prepared by an advanced polymerization technique, Reversible Addition Fragmentation Chain Transfer (RAFT). Analytical tools provide the evidence that phosphate ligands completely replaced all the oleic acid capping molecules on the surface of the UCNPs compared with incomplete ligand exchange by carboxylic and sulphonic acid groups. Meanwhile, simulated quantitative adsorption energy measurements confirmed that among the three functional groups, the calculated adsorption strength for phosphate anchoring ligands is higher which is in good agreement with experimental results regarding the best colloidal stability, especially in phosphate buffer solution. This finding suggests that polymers with multiple anchoring negatively charged phosphate moieties provide excellent colloidal stability for lanthanide ion-doped luminescent nanoparticles for various potential applications.

Graphical abstract: Systematic investigation of functional ligands for colloidal stable upconversion nanoparticles

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Publication details

The article was received on 30 Dec 2017, accepted on 17 Jan 2018 and first published on 26 Jan 2018


Article type: Paper
DOI: 10.1039/C7RA13765F
Citation: RSC Adv., 2018,8, 4842-4849
  • Open access: Creative Commons BY license
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    Systematic investigation of functional ligands for colloidal stable upconversion nanoparticles

    H. T. T. Duong, Y. Chen, S. A. Tawfik, S. Wen, M. Parviz, O. Shimoni and D. Jin, RSC Adv., 2018, 8, 4842
    DOI: 10.1039/C7RA13765F

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