AgBF4-catalyzed deoxygenative C2-amination of quinoline N-oxides with isothiocyanates

Abstract

A general, effective and convenient protocol for the direct synthesis of various 2-aminoquinolines (39 examples) through AgBF₄-catalyzed amination of quinoline N-oxides with isothiocyanates under base-, oxidant-free and mild conditions was developed. The transformation could be performed on a gram-scale and in a sequential manner starting from quinoline N-oxide to the synthesis of benzo[4,5]imidazo[1,2-a]quinoline.