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DDQ-mediated direct C(sp3)–H phosphorylation of xanthene derivatives

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Abstract

A convenient and efficient C(sp3)–H phosphorylation has been achieved via the metal-free DDQ-mediated cross-dehydrogenative coupling between diarylphosphine oxides and xanthene derivatives at room temperature. This transformation provides a direct synthetic route to the construction of C(sp3)–P bonds with good functional group compatibility, leading to the formation of alkylphosphonates in up to 96% yield.

Graphical abstract: DDQ-mediated direct C(sp3)–H phosphorylation of xanthene derivatives

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Publication details

The article was received on 19 Jul 2018, accepted on 07 Aug 2018 and first published on 08 Aug 2018


Article type: Research Article
DOI: 10.1039/C8QO00740C
Citation: Org. Chem. Front., 2018, Advance Article
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    DDQ-mediated direct C(sp3)–H phosphorylation of xanthene derivatives

    Q. Chen, X. Wang, G. Yu, C. Wen and Y. Huo, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00740C

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