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Preparation of fluoroalkoxy or fluorophenoxy substituted N-heterocycles from heterocyclic N-oxides and polyfluoroalcohols

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Abstract

A novel and efficient approach to introduce fluorine-containing groups into N-heterocycles was reported. In this work, appropriate polyfluoroalcohols were used as the fluorine source, PyBroP as the activating agent, DCE as the solvent and silver carbonate as the base. The obvious advantage of the process is that the fluorination compounds were produced in moderate to good yields and with excellent regioselectivity in most cases. Moreover, this reaction also features remarkable functional group compatibility and broad substrate scope.

Graphical abstract: Preparation of fluoroalkoxy or fluorophenoxy substituted N-heterocycles from heterocyclic N-oxides and polyfluoroalcohols

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Publication details

The article was received on 19 May 2018, accepted on 20 Jun 2018 and first published on 21 Jun 2018


Article type: Research Article
DOI: 10.1039/C8QO00499D
Citation: Org. Chem. Front., 2018, Advance Article
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    Preparation of fluoroalkoxy or fluorophenoxy substituted N-heterocycles from heterocyclic N-oxides and polyfluoroalcohols

    D. Zhang, K. Qiao, J. Hua, Z. Liu, H. Qi, Z. Yang, N. Zhu, Z. Fang and K. Guo, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00499D

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