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Issue 13, 2018
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Pd-catalyzed carbonylation of aryl C–H bonds in benzamides with CO2

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Abstract

Herein, we report the first Pd-catalyzed carbonylation of unactivated aryl C–H bonds in benzamides under 1 atm of CO2 to directly afford important phthalimides. A variety of phthalimides are synthesized in moderate to high yields under redox-neutral conditions. This transformation features high regio- and chemo-selectivity, step-economy, good functional group tolerance, broad substrate scope and smooth scalability. Mechanistic studies suggest that the palladacycle is a competent intermediate.

Graphical abstract: Pd-catalyzed carbonylation of aryl C–H bonds in benzamides with CO2

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Publication details

The article was received on 28 Apr 2018, accepted on 15 May 2018 and first published on 29 May 2018


Article type: Research Article
DOI: 10.1039/C8QO00433A
Citation: Org. Chem. Front., 2018,5, 2086-2090
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    Pd-catalyzed carbonylation of aryl C–H bonds in benzamides with CO2

    L. Song, G. Cao, W. Zhou, J. Ye, Z. Zhang, X. Tian, J. Li and D. Yu, Org. Chem. Front., 2018, 5, 2086
    DOI: 10.1039/C8QO00433A

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